Endocrine Abstracts

Obestatin is a 23-amino acid amidated peptide that is encoded by the ghrelin gene and was therefore presumed to have regulatory effects on pituitary. However, the limited set of studies performed hitherto suggests that obestatin has no major effect on hormone secretion, in vivo or in vitro, from rodent pituitary, whereas no comparable data is still available on primates. Here, primary pituitary cell cultures from a non-human primate (baboon; Papio anubis) served ...

Neuroendocrine balance of the hypothalamo-pituitary-adrenal axis (HPA) is a critical component in the control of metabolic homeostasis, and its dysregulation can contribute to severe pathologies, like obesity, where the HPA is significantly altered at the central and systemic levels. Somatostatin and cortistatin have been shown to reduce circulating ACTH and glucocorticoid-levels in rodents and humans in vivo. However, to date, no studies have thoroughly investigated and compa...